Anti-Inflammatory Drug Discovery

Anti-Inflammatory Drug Discovery provides a comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and so provides a key reference for those involved or interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action. The editors, with extensive experience in this field, have selected key thought-leaders who will bring their knowledge to the medicinal chemistry literature based on their own personal experience with each target, ranging from components of the arachadonic acid cascade, to kinases, GPCRs, sphingolipids and others. They summarize the target's background biology and detail new insights, major advances and other issues related to bringing new anti-inflammatory therapies to market. Consisting of five main sections, the key targets covered will include: AA Cascade: mPGES1, cPLA2, Leukotriene A4 Hydrolase, CRTH2 Kinases: P38/PDE4, MAPKAP Kinase 2 (MK2), Syk Kinase Inhibitors, Jak Kinases, IKK, Bruton's Tyrosine Kinase GPCRs: CCR1, CCR2 Antagonists, CB2 Agonists Sphingolipids: S1P1 Receptor Agonists, Sphingosine Lyase and Sphingosine Kinase 1 Miscellaneous: Non-Steroidal Dissociated Glucocorticoid Receptor Agonists. The book will be essential reading for pharmacologists, medicinal chemists and pharmaceutical scientists working in industry and academia.