Attempts to Understand Metastasis Formation II Regulatory Factors

Within the last decade molecular biology of tumor models has revealed the identification of several metastasis-related molecules. This current series attempts to review the most recent approaches of their mechanisms, regulation and way to treat their malignant alterations.
The first volume covers the presentation of proteases and inhibitors and their role in invasion of tumor cells, as well as cell adhesion molecules and their interaction with the extracellular matrix.
In this, the second volume the regulation of tumor progression and angiogenesis by cytokines, growth factors and motility factors is outlined, followed by a compilation of metastasis-related molecules located in the cytoplasm and the nucleus.
The third volume covers detection of micrometastasis and therapeutic approaches, such as immunotherapy, gene therapy, chemotherapy and surgical strategies, to combat metastatic spread.