Free Radicals in Diagnostic Medicine A Systems Approach to Laboratory Technology, Clinical Correlations, and Antioxidant Therapy

Pathophysiology and Analysis.- Lipid Peroxides and Related Radicals in Clinical Medicine.- Reactive Oxygen Species in Normal Physiology, Cell Injury and Phagocytosis.- Free Radical Mechanisms for Chromosomal Instability in Bloom's Syndrome.- The Analysis of Free Radicals, Lipid Peroxides, Antioxidant Enzymes and Compounds Related to Oxidative Stress as Applied to the Clinical Chemistry Laboratory.- Organ Specific Disorders.- Free Radicals and the Pathogenesis of Neuronal Death: Cooperative Role of Excitatory Amino Acids>.- Free Radicals and Ocular Disease.- Active Oxygen Mechanisms of UV Inflammation.- Oxygen-Free Radicals at Myocardial Level: Effects of Ischaemia and Reperfusion.- Mechanisms of Atherosclerosis: Role of LDL Oxidation.- Tissue Iron Overload and Mechanisms of Iron-Catalyzed Oxidative Injury.- Free Radicals in the Pathophysiology of Pulmonary Injury and Disease.- Lipid Peroxides in Hepatic, Gastrointestinal, and Pancreatic Diseases.- Reactive Oxygen Molecules in the Kidney.- Reactive Oxygen Species (ROS) and Reproduction.- Systemic Involvement.- Autoimmune and Inflammatory Diseases.- Antioxidants and Cancer: Molecular Mechanisms.- New Directions for Free Radical Cancer Research and Medical Applications.- Shock and Multiple Organ Failure.- Role of Nutrients in the Cause and Prevention of Oxygen Radical Pathology.- Involvement of Free Radical Mechanism in the Toxic Effects of Alcohol: Implications for Fetal Alcohol Syndrome.- Therapeutic Intervention.- 21-Aminosteroids ("Lazaroids").- The Potential of Gliclazide, a Sulphonylurea to Influence the Oxidative Processes within the Pathogenesis of Diabetic Vascular Disease.- Interactions between Vitamin E, Free Radicals, and Immunity During the Aging Process.- Vitamins and Carotenoids - A Promising Approach to Reducing the Risk of Coronary Heart Disease, Cancer and Eye Diseases.- Free Radical Scavenging and Antioxidant Activity of Plant Flavonoids.- Plasma Clearance and Immunologic Properties of Long-Acting Superoxide Dismutase Prepared Using 35,000 to 120,000 Dalton Poly-Ethylene Glycol.- Clinical Trials with Dismutec(TM) (Pegorgotein; Polyethylene Glycol-Conjugated Superoxide Dismutase; PEG-SOD) in the Treatment of Severe Closed Head Injury.- Poster Presentations.- A New Method for Detecting Lipid Peroxidation by Using Dye Sensitized Chemiluminescence.- Chemiluminescence and the Challenge to Attomole Detection.- Evidence Against Malondialdehyde Bound to Cellular Consituents in Phospholipid Peroxidation.- Evaluation of In Vivo Free Radical Activity During Endotoxic Schock Using Scavengers, Electron Microscopy, Spin Traps, and Electron Paramagnetic Spectroscopy.- Involvement of Hydroxyl Radicals in Endotoxin-Evoked Shock.- The Role of Nitric Oxide in Endotoxin-Elicited Hypodynamic Circulatory Failure.- In Vivo Evaluation of the Role of Neutrophil-Derived Free Radicals in the Development of Endotoxic Shock.- Photosensitized Formation of 8-Hydroxy-2'-Deoxyguanosine by A Cationic meso-Substituted Porphyrin.- Aging Associated Declines in the Antioxidant Enzymes of Human Testis.- Lipid Peroxidation in Normal Pregnancy and Preeclampsia.- Alkylation of Purine Bases By Carbon-Centered Radicals.- Cytochrome Biochemistry in Sheep Retina Following Exposure to Oxygen.- Cytochrome Oxidase Activity in the Fetal Sheep Retina.- Age-Related Phospholipid Hydroperoxide Levels in Gerbil Brain Measured by HPLC-Chemiluminescence Assay and Their Relation to Hydroxyl Radical Stress - Clinical Implications.- Lipid Peroxidation and Diabetic Complications: Effect of Antioxidant Vitamins C and E.- Vascular Complications of Patients in Kuwait with Type 2 Diabetes Mellitus (NIDDM) and Elevated Serum Lipid Peroxides.- Vascular and Cellular Protein Changes Precede Hippocampal Pyramidal Cell Loss Following Global Ischemia in the Rat.- Dietary Antioxidants and Breast Cancer Risk: Effect Modification by Family History.- Effect of MAK-4 and MAK-5 on Endothelial Cell- and Soyabean Lipoxygenase-Induced LDL Ox