Gallopamil Pharmacological and Clinical Profile of a Calcium Antagonist

Sinee the introduetion of Gallopamil in 1983 this drug has been applied in similar indications as Verapamil. Predominantly pat­ ients with stable or unstable angina peetoris, with hypertension, and hypertrophie eardiomyopathy have been treated. As far as ean be judged from preliminary clinieal experienee Gallopamil aehieves similar results as Verapamil with mueh lower doses. Instead of 3 times 160 mg Verapamil 2 to 3 times 50 mg Gallopamil ean be applied. Although the speetrum of side effects ofboth drugs is similar it is evident that oeeasionally patients ean tolerate one better than the other. Complaints about eonstipation may be less frequent with Gallopamil whereas stomaeh trouble may be more frequent. Frankfurt, August 1984 M. KALTENBACH R. HOPF v Table of Contents Gallopamil (D 600) - a Calcium Antagonist of High Potency and Specificity. Effects on the Myocardium and Pacemakers (A. FLECKENSTEIN, B. FLECKENSTEIN, F. SPÄH and Y. K. BYON). . . . . . . . . . . . . . . . . . . . . . . . 1 2 Blockade ofthe Ca + -dependent Bioelectrical Automaticity and Electromechanical Coupling of Smooth Musc1e Cells by Gallopamil (D 600) (G. FLECKENSTEIN-GRÜN and A. FLECKENS TEIN) . . . . . . . . . . . . . . . . . . . . . . . 33 Studies on the Mechanism of Action of D 600 on Isolated Myocytes (W. TRAUTWEIN and J. HESCHELER) . . . . . . . 49 Studies In Vitra and In Vivo on the Effect of Gallopamil on Coranary Vessels (A. G. B. Kov ACH, L. LIGETI, M. BAKOS, G. RUBANYI and A. KOLLER) . . . . . . . . . . . . . . . . . . 58 Electraphysiological Studies with Gallopamil on the Myocardium ofthe Human Ventric1e (H. NAWRATH and XIAN-GANG ZONG) . . . . . . . . . . . . . . . . . . . . . . .