Resistance to Molecular Therapies for Hepatocellular Carcinoma
Description
This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.
Keywords
MedicalOncology
2017Book
Author(s)Augusto Villanueva
PublisherSpringer International Publishing
ISBN9783319561967
LanguageEnglish
