Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

Twenty papers comprise the proceedings of the Institute, held August to September 1997 in Antalya, Turkey. The third in a series of gatherings on the enzymes of oxidative metabolism of xenobiotics, it put greater emphasis on the human enzyme of oxidative xenobiotic biotransformation, including the flavin- containing monooxygenases and particularly those of the cytochrome P450 family. It also highlighted the potential dangers of polymorphisms in the enzymes. The topics include correlations between in-vivo and in-vitro studies in human drug metabolism, clinical aspects of polymorphic drug metabolism in humans, insecticide metabolism in insects and mammals and the role of cytochrome P450 isoforms in insecticide resistance, and the role of individual enzymes in the control of genotoxic metabolites. Annotation copyrighted by Book News, Inc., Portland, OR