The Genetics of Type 2 Diabetes and Related Traits Biology, Physiology and Translation

The field of human genetics has witnessed tremendous acceleration in the last decade. The parallel advances in genotyping and sequencing technology, our understanding of human genetic variation, and the statistical methodologies needed to interpret genetic findings have led to a veritable explosion of genetic discovery. In few other diseases have the issues raised by these results become as paramount as in type 2 diabetes, where the elucidation of its genetic architecture, its transferrability across populations, the role of intermediate quantitative traits, the relative impact of environmental factors, the laborious progress from genetic association to function, and the clinical translation of genetic findings have met with both challenging obstacles and creative solutions. This book captures the state of the art of type 2 diabetes genetics, from the process of genetic discovery through its interpretation to its clinical application, and illustrates the path for other complex human phenotypes. ​