Integrin-Ligand Interaction (Molecular Biology Intelligence Unit)

The fate of cells is largely controlled by the extracellular matrix. Cells recognize matrix constituents via integrins, a large family of receptors. The manifold structural requirements necessary for the specific interaction between distinct integrins and their respective matrix ligands, as well as the subsequent signal transduction pathways and their influence on cell adhesion, migration and morphology, are the main subjects of this book. It emphasizes in particular the importance of the three-dimensional structure and the conformation of the integrin recognition sites within the ligands; this provides new aspects to our understanding of the high specificity of the communication of cells with distinct members of the extracellular matrix.