Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

The ability of neoplastic cells to survive exposure to various chemotherapeutic drugs represents the main obstacle to successful cancer chemotherapy. These essays summarize the results of molecular biological, pharmacological, biochemical, cytogenetic, immunological, and pathological studies on multidrug resistance in mammalian cells. Most chapters deal with the structure and expression of P-glyco-protein and its role in multidrug resistance. Other chapters describe additional changes in multidrug resistant cells which may or may not be related to P-glycoprotein expression. The final chapters discuss strategies for reversing clinical multidrug resistance. Annotation copyright Book News, Inc. Portland, Or.