Carbohydrate Chemistry, Part 1 (Specialist Periodical Reports, Volume 17)

Product Description


Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Glycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate-based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist.


Excerpt. © Reprinted by permission. All rights reserved.


Carbohydrate Chemistry Volume 17
Part I Mono-, Di-, and Tri-saccharides and Their Derivatives

By N. R. Williams
The Royal Society of Chemistry


Copyright © 1985 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-0-85186-182-1


Contents

1 Introduction, 1,
2 Free Sugars, 2,
3 Glycosides and Disaccharides, 15,
4 Oligosaccharides, 44,
5 Ethers and Anhydro-sugars, 54,
6 Acetals, 63,
7 Esters, 67,
8 Halogeno-sugars, 81,
9 Amino-sugars, 90,
10 Miscellaneous Nitrogen Derivatives, 104,
11 Thio-sugars, 116,
12 Deoxy-sugars, 120,
13 Unsaturated Derivatives, 125,
14 Branched-chain Sugars, 131,
15 Aldosuloses, Dialdoses, and Diuloses, 141,
16 Sugar Acids and Lactones, 146,
17 Inorganic Derivatives, 154,
18 Alditols and Cyclitols, 159,
19 Antibiotics, 171,
20 Nucleosides, 186,
21 N.M.R. Spectroscopy and Conformational Features, 205,
22 Other Physical Methods, 219,
23 Separatory and Analytical Methods, 229,
24 Synthesis of Enantiomerically Pure Non-carbohydrate Compounds, 244,
Author Index, 257,





CHAPTER 1
Introduction

We have abstracted over 1400 references in carbohydrate chemistry for 1983. The areas of interest reflected in these references have confirmed the trends apparent in recent years. Besides the well-established fields of glycoside, nucleoside, and antibiotic chemistry, there has been a rapid increase in papers reporting the synthesis of chiral natural products from carbohydrate precursors, and a separate chapter on oligosaccharides has clearly justified its inclusion. Incidentally, these last two chapters have both resulted from suggestions made to us by interested readers, and we would like to encourage further participation of this kind. The emphasis in these areas should not obscure the fact that many other aspects of monosaccharide and oligosaccharide chemistry continue to attract much interest, as is demonstrated by the fact that only six of the twenty-four chapters in this volume contain fewer than thirty references.
An appreciation of the life and work of J.K.N.Jones has been published.
Reviews covering general aspects of carbohydrate chemistry have included a survey of nucleophilic substitution reactions in carbohydrate derivatives, discussions of the role of lone-pair interactions in the selective functionalization of hexopyranosides in esterification and etherification reactions, and a review of some studies in asymmetric synthesis, Diels-Alder reactions, and stereospecific sugar synthesis.CHAPTER 2
Free Sugars

A review of the structures and nomenclature of the sugars of honey has appeared.

1 Synthesis
Two reviews on the synthesis and utilization of sugars produced by the formose reaction have appeared. The use of chemical ionization - m.s. to characterize the products of the formose reaction has been described. A report of a study on the catalytic activity of rare earth elemen